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7. TYPICAL DERANGEMENTS OF CARBOHYDRATE METABOLISM. DIABETES MELLITUS

I. Hyperglycemia can be induced by the excessive production of the following hormones:

1. Epinephrine.

2. Thyroid hormones.

3. Growth hormone.

4. Insulin.

5. Glucocorticoids.

6. Antidiuretic hormone.

7. Glucagon.

II. Insulin exerts the following metabolic effects:

1. An increase in glucose uptake.

2. An increase in the production of ketone bodies.

3. Inhibition of glycogenolysis.

4. Activation of glycogenesis.

5. Activation of gluconeogenesis.

6. Activation of glucose utilization.

7. Stimulation of free fatty acids oxidation.

8. Stimulation of synthesis and release of lipoprotein lipase.

III. Which of the following disturbances are the most important in the pathogenesis of diabetic hyperosmolar coma?

1. Hypernatremia.

2. Hyperkalemia.

3. Acidosis.

4. Hyperglycemia.

5. Intracellular hyperosmia.

6. Extracellular hyperosmia.

7. Intracellular hypohydration.

IV. Which of the following disturbances are the most important in the pathogenesis of coma in type I diabetes?

1. Hypernatremia.

2. Hyperkalemia.

3. Ketonemia.

4. Hyperglycemia.

5. Acidosis.

V. Which of the following manifestations are the most typical for type I diabetes?

1. Polyuria.

2. Polydipsia.

3. Polyphagia.

4. Positive energy balance.

5. Muscle weakness.

6. Ketonemia.

7. Hypoosmia of plasma.

VI. Which of the following factors promote diabetic microangiopathy?

1. Nonenzymic glycation.

2. Hyperlipoproteinemia.

3. Dislipoproteinemia.

4. Deposition of sorbitol in the endothelial cells.

5. Increased collagen synthesis in the vessel wall leading to a decrease in its permeability.

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