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7.   TYPICAL DERANGEMENTS OF CARBOHYDRATE METABOLISM. DIABETES MELLITUS

I. Hyperglycemia can be induced by the excessive production of the following hormones:

1. Epinephrine.

2. Thyroid hormones.

3. Growth hormone.

4. Insulin.

5. Glucocorticoids.

6. Antidiuretic hormone.

7. Glucagon.

II. Insulin exerts the following metabolic effects:

1. An increase in glucose uptake.

2. An increase in the production of ketone bodies.

3. Inhibition of glycogenolysis.

4. Activation of glycogenesis.

5. Activation of gluconeogenesis.

6. Activation of glucose utilization.

7. Stimulation of free fatty acids oxidation.

8. Stimulation of synthesis and release of lipoprotein lipase.

III. The most important pathogenic factors in diabetic hyperosmolar coma are:

1. Hypernatremia.

2. Hyperkalemia.

3. Acidosis.

4. Hyperglycemia.

5. High intracellular osmotic pressure.

6. High extracellular osmotic pressure.

7. Intracellular hypohydration, dehydration.

IV. The most important pathogenic factors in diabetic mellitus type I are:

1. Hypernatremia.

2. Hyperkalemia.

3. Ketonemia.

4. Hyperglycemia.

5. Acidosis.

6. Dehydration.

V. Which of the following manifestations are the most typical for type I diabetes?

1. Polyuria.

2. Polydipsia.

3. Polyphagia.

4. Positive energy balance.

5. Muscle weakness.

6. Ketonemia.

7. Low plasma osmotic pressure.

VI. Which of the following factors promote diabetic microangiopathy?

1. Nonenzymic glycation.

2. Hyperlipoproteinemia.

3. Dislipoproteinemia.

4. Deposition of sorbitol in the endothelial cells.

5. Increased collagen synthesis in the vessel wall leading to a decrease in its permeability.

VII. Which of the following complications are common for type I diabetes mellitus?

1. Microangiopathy.

2. Retinopathy.

3. Liver dysfunction.

4. Neuropathy.

5. Atherosclerosis.

6. Hypotension.

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