Questions to prepare for classes and examination
• The main stages of leukopoiesis and its regulation by humoral factors.
• Classification of disorders of white blood cells.
• Leukopenia: definition and causes.
• General mechanisms of leukopenia.
• Causes and mechanisms of a decreased leukocytes production.
• Causes and mechanisms of an increased peripheral destruction of leukocytes.
• Signs and consequenses of neutropenia.
• Leukocytosis: causes and mechanisms.
• Causes of increased production in the bone marrow, mobilization, and defective margination of neutrophils.
• Types of leukocytosis; patterns of shift to the left.
• Biological significance of leukocytosis.
• Types and mechanisms of abnormal neutrophil function.
• Leukemoid reactions: typical features, causes, mechanisms of development, physiological significance.
• Changes in the complete blood test with differential. Absolute and relative shifts in leukocytes count.
N 72
A 38-year-old male industrial worker visited his general practitioner. The patient was a victim of fire at his working place. During the accident he had received epidermal and partial thickness burns of the right side of the body (about 10% of the total body surface area). His condition was fair, the body temperature was 37.8 °C. On the fifth day the patient's condition deteriorated due to an intercurrent infection of the burnt wound. He developed signs of
marked purulent, exudative inflammation of the derma and subcutaneous tissue; his body temperature elevated to 40.2 °C. Blood tests were taken twice at different time points. The following results were obtained:
Questions
• Evaluate the results of the tests A and B and make a conclusion to each of them. What is the difference between these two analyses?